Hutton and Naismith have been on the periphery of the first team in the opening phase of the campaign.
Midfielder Hutton started the Ramsdens Cup tie at Brechin back in July but has not featured since then while striker Naismith has had three substitute appearances.
Both should start the Reserve League opener at Annan’s Galabank Stadium.
Coach Tommy Wilson said: “It’s the ideal chance for players like Kyle Hutton and Kal Naismith – boys that I know well – to get some game time and maybe show the first team coaching staff how they can perform on the surface that the first team will play on this weekend.”
Rangers will play 13 Reserve League matches this season – seven away at six at home with most of the home game taking place at the Training Centre.
There is no age restriction so Ally McCoist may choose to give first team stars match action from time to time.
Wilson added: “We are hoping to play our home games at Murray Park on Pitch One but one of the issues is the lighting.
“We are taking steps to sort that out and I’m sure that teams that come here will really enjoy it.
“We might play the odd game at Ibrox – and I hope we do and maybe get a bit of a crowd.”