Francisco Sandaza makes his first start as a Rangers player with Barrie McKay dropping to the bench to make way for the Spaniard.
Lewis Macleod retains his place in midfield but Sandaza's inclusion would allow a variety of formations to be employed by McCoist.
It could see a return to midfield for Lee McCulloch, with Andy Little given more freedom to attack.
However Lee Wallace's energy on the left side could see the Rangers boss retain the back three he has favoured recently.
McKay has a place on the bench along with Emilson Cribari, with the Brazilian defender seeking his Rangers debut.
Rangers: Alexander; Broadfoot, Goian, Bocanegra, Wallace; Little, Black, Macleod Shiels; Sandaza, McCulloch.
Subs: Gallacher, Emilson, Crawford, McKay, Kyle