Chris Hegarty also makes the step up to the starting XI in place of Sebastien Faure with the Frenchman out of the squad altogether.
Fraser Aird drops to the bench to make way for Little as the formation switches to 4-3-3.
Little and Dean Shiels will join Lee McCulloch in a three man front line with Kyle Hutton retaining his place in midfield.
Hutton will feature with Ian Black and Lewis Macleod either side of him in the heart of the pitch.
In defence, Lee Wallace is again at left back while Hegarty takes his position on the opposite flank in place of Faure.
Ross Perry and Emilson Cribari are again at the heart of the back line in front of Neil Alexander in goal.
Rangers: Alexander; Hegarty, Perry, Cribari, Wallace; Black, Hutton, Macleod; Little, McCulloch, Shiels.
Subs: Gallacher, Argyriou, McKay, Aird, Kyle.
Clyde: Barclay, Brown, Sharp, Oliver, Marsh, Hay, Neill, Sweeney, McCluskey, Gilfillan, McColm.
Subs: Rajovic, Watt, Fitzharris, Scullion, Kane.