The Light Blues will come up against Terry Butcher’s side in the quarter-finals looking to record their fourth victory in the tournament so far this season.
While triumphs against East Fife and Falkirk in their early matches perhaps weren’t wholly surprising, the 2-0 dismissal of Well last time out was deemed to be a shock.
Caley Jags will come to Glasgow lying fifth in the SPL and having scored in each of their 13 competitive games so far this term.
When Gers beat the Steelmen in the third round, they came out on top against a side which sat at the top flight summit at that point.
Now Inverness are above the men from Fir Park and MacDonald is of the opinion levels will need to be raised yet again if they are to be eliminated.
The former Ibrox midfielder said: “I think all the pressure will be on Inverness to stay on their good run.
“Rangers are a Third Division team and they’ve had one or two problems this season so I don’t think everyone will be expecting them to win.
“When you play a Premier League side as a team from the lower divisions, it is usually the club from the higher league that’s favourite to win.
“I think that’s the case here and without doubt, Rangers are going to have to eclipse their performance against Motherwell in the last round if they are to get through.
“There isn’t the same pressure on them to win and from that point of view, they just need to get out there and get on with it. Hopefully they can win.
“It would be great for them to get to the semi-finals and the fact expectations are maybe lower than normal might help the players rather than hinder them.
“There’s still pressure to deal with when you are at Rangers. There’s pressure when you get in a taxi or walk along the street, never mind when you’re on the pitch.
“For all that, most will think that Inverness should come out on top but you’ve always got to believe you can win.”
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