Coming into the side today are Filip Helander, Borna Barisic, Glen Kamara, Steven Davis and Jermain Defoe.
They take the places of the injured Leon Balogun, Calvin Bassey, Bongani Zungu, Joe Aribo and Cedric Itten.
That means its a back five of Allan McGregor in goal with James Tavernier, Connor Goldson, Helander and Barisic in front of him.
Scott Arfield is joined by Davis and Kamara in midfield, while up front, Kemar Roofe and Ryan Kent will support Defoe.
Bassey, Zungu, Aribo and Itten make the bench, and they are joined there by Jon McLaughlin, Ianis Hagi, Nathan Patterson, Brandon Barker and Greg Stewart.
It’s a 3pm kick-off here in Govan - join Emma Dodds with guests Neil McCann and Shelley Kerr before Tom Miller and Kevin Thomson bring you full coverage.
RANGERS: McGregor, Tavernier, Goldson, Helander, Barisic, Arfield, Davis, Kamara, Roofe, Kent, Defoe.
SUBS: McLaughlin, Bassey, Hagi, Itten, Zungu, Patterson, Aribo, Barker, Stewart.
RangersTV will bring you all the action from today's match LIVE wherever you are in the world!
If you aren't a season ticket holder the broadcast will also be available to purchase on Pay-Per-View for £9.99 if you are inside the UK, and internationally with a RangersTV Unlimied subscription or via Pay-Per-View.
You can find out more and purchase your PPV match pass HERE.
Joining Emma Dodds for the match at Ibrox will be fans’ favourite Neil McCann, and alongside him, making a RangersTV return, will be current Scotland Women’s Manager Shelly Kerr.
Tom Miller will continue on commentary duty with current joint B team coach, Kevin Thomson, joining him on co-Comms.
Rangers will play Motherwell for the third time this season, having defeated the Steelmen in a preseason friendly before winning 5-1 at Fir Park in September.