It is the second meeting between the two rivals this season, as the Gers look to claim the city bragging rights by coming out victorious having played out a 2-2 draw in the same fixture at the start of October.
From the side that booked their place in the Sky Sports Cup semi-finals last weekend, there are two changes. Jenna Fife replaces Victoria Esson in goal and Kathy Hill comes into the team in place of Tessel Middag.
The Light Blues are also boosted with the return of midfielder Chelsea Cornet, who appears in a matchday squad for the first time since August after recovering from injury.
That means Jenna Fife starts in goal, with captain Nicola Docherty, Leah Eddie and Kathy Hill all in from the off.
Brogan Hay is in the lineup, and is joined by Charlie Devlin, Rio Hardy and Kirsty Maclean.
Liv McLoughlin continues in the side, with Jodi McLeary and top goal scorer Katie Wilkinson completing the XI.
On the substitutes bench for Rangers is Victoria Esson, Laura Rafferty, Tessel Middag, Kirsty Howat, Jane Ross, Mia McAulay, Lizzie Arnot, Chelsea Cornet and Camille Lafaix.
Kick off in Hamilton is at 12 noon and you can watch all the action unfold live on Sky Sports.
RANGERS: Fife, Docherty, Eddie, Hill, Hay, Devlin, Hardy, Maclean, McLoughlin, McLeary, Wilkinson
SUBS: Esson, Rafferty, Middag, Howat, Ross, McAulay, Arnot, Cornet, Lafaix