The competition represents the first chance of silverware for the side this term and they will be keen to retain their grip on the trophy that they have lifted on the previous two occasions.
Vic Esson starts between the posts, while there are starts for Nicola Docherty, Leah Eddie and Tessel Middag.
Brogan Hay is given the nod, alongside Charlie Devlin, Rio Hardy and Kirsty Maclean.
There is also a start for Liv McLoughlin, while Jodi McLeary and Katie Wilkinson start from the off.
Among the substitutes for the Gers are Jenna Fife, Kathy Hill, Laura Rafferty, Kirsty Howat, Jane Ross, Mia McAulay, Lizzie Arnot, Eilidh Austin and Camille Lafaix.
Kick-off in East Kilbride is 7:45pm and you can stay up to date with the action on X @RangersWFC.
RANGERS: Esson, Docherty, Eddie, Middag, Hay, Devlin, Hardy, Maclean, McLoughlin, McLeary, Wilkinson
SUBS: Fife, Hill, Rafferty, Howat, Ross, McAulay, Arnot, Austin, Lafaix