Steven Davis, Borna Barisic and Scott Arfield replace Ben Davies, Ridvan Yilmaz and John Lundstram as the Light Blues look to sign off with a victory in front of a home crowd.
It means Allan McGregor retains his place between the posts, behind a backline of James Tavernier, James Sands, Leon King and Barisic.
The experienced Davis anchors the midfield, with the Northern Irishman joined by Arfield and Malik Tillman.
It’s an unchanged forward line from the victory over Aberdeen in the Scottish Premiership at the weekend, with Antonio Colak leading the charge alongside Ryan Kent and Fashion Jr.
Among the substitutes for Rangers are Jon McLaughlin, Robby McCrorie, Adam Devine, Robbie Fraser, Connor Allan, Glen Kamara, Alex Lowry, Rabbi Matondo, Alfredo Morelos and Scott Wright.
RANGERS: McGregor, Tavernier, Sands, King, Barisic, Davis, Arfield, Tillman, Fashion Jr., Colak, Kent.
SUBS: McLaughlin, McCrorie, Devine, Fraser, Allan, Kamara, Lowry, Matondo, Morelos, Wright.