It is a huge tie between the two rivals, as the Light Blues look to take a step closer to retaining the trophy they have won in the previous two campaigns.
From the side that ran out dominant winners upon their return from the winter break last weekend, the head coach has made two changes with top goalscorer Katie Wilkinson coming into the lineup in place of Kirsty Howat, whilst Kathy Hill is in for Laura Rafferty.
That means that Victoria Esson retains her place between the posts, with captain Nicola Docherty, Leah Eddie and Hill in from the off.
Brogan Hay is in the side and is joined by Rio Hardy, Mia McAulay and Lizzie Arnot.
Chelsea Cornet starts in the derby once again after scoring the winner when the two teams last met, with Liv McLoughlin and Wilkinson completing the lineup.
On the substitutes bench for Rangers this afternoon is Jenna Fife, Laura Rafferty, Tessel Middag, Kirsty Howat, Megan Bell, Jane Ross, Sarah Ewens, Camille Lafaix and Jodi McLeary.
Kick off in Hamilton is at 4.10pm and you can watch all the action live on BBC ALBA.
RANGERS: Esson, Docherty, Eddie, Hill, Hay, Hardy, McAulay, Arnot, Cornet, McLoughlin, Wilkinson
SUBS: Fife, Rafferty, Middag, Howat, Bell, Ross, Ewens, Lafaix, McLeary